Used primarily in biochemical and pharmacological research to study peroxisome proliferator-activated receptor gamma (PPARγ) pathways. It acts as a selective PPARγ antagonist, helping to modulate insulin sensitivity, adipogenesis, and inflammation in cellular models. Commonly applied in studies related to metabolic disorders, diabetes, and obesity to investigate the role of PPARγ without inducing full agonist effects. Also utilized in cancer research due to PPARγ's involvement in cell proliferation and differentiation.