Azoramide
10mM in DMSO
Reagent
Code: #134250
CAS Number
932986-18-0
blur_circular Chemical Specifications
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Molecular Information
Weight
308.83 g/mol
Formula
C₁₅H₁₇ClN₂OS
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Registry Numbers
MDL Number
MFCD08009374
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Storage & Handling
Storage
-20°C
description Product Description
Azoramide is primarily investigated for its potential in treating metabolic disorders, particularly type 2 diabetes. It functions as an endoplasmic reticulum (ER) stress reducer, helping to restore protein folding balance in cells. This action is especially beneficial in pancreatic beta cells, where chronic ER stress can impair insulin production and lead to cell death. By alleviating ER stress, Azoramide enhances insulin secretion and improves glucose homeostasis.
It has also shown promise in preclinical studies for neurodegenerative diseases, where protein misfolding and ER stress contribute to neuronal damage. Additionally, Azoramide may have protective effects in conditions involving cellular stress, such as certain liver diseases and inflammatory responses. Its ability to modulate cellular stress pathways makes it a candidate for therapeutic development in multiple chronic diseases linked to proteostasis imbalance.
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