MMP-3 inhibitors are primarily used in research and therapeutic applications targeting diseases where matrix metalloproteinase-3 (MMP-3) activity is elevated. This enzyme is implicated in the breakdown of extracellular matrix components, contributing to tissue degradation in conditions such as arthritis, cancer metastasis, and cardiovascular diseases. By inhibiting MMP-3, these compounds help reduce inflammation, slow tumor progression, and prevent tissue damage. They are also studied for their potential in treating neurodegenerative disorders, as MMP-3 is involved in neuronal injury and inflammation. Additionally, MMP-3 inhibitors are explored in wound healing and tissue repair processes, where controlling excessive MMP activity is crucial for proper recovery.