PD 151746 is primarily used in research settings as a selective inhibitor of p38 MAP kinase, a key enzyme involved in cellular stress responses. Its application is significant in studying inflammatory pathways, as p38 MAP kinase plays a crucial role in the production of pro-inflammatory cytokines. Researchers utilize this compound to explore its potential in mitigating inflammation-related diseases, such as rheumatoid arthritis and chronic obstructive pulmonary disease (COPD). Additionally, it aids in understanding the molecular mechanisms underlying cell signaling and stress responses, contributing to the development of targeted therapies for various conditions.