p38-α MAPK-IN-1 is primarily used in research settings to study the p38 MAPK signaling pathway, which plays a critical role in cellular responses to stress and inflammation. It is employed as a selective inhibitor to investigate the biological functions of p38-α MAPK in various disease models, including inflammatory disorders, cancer, and neurodegenerative diseases. By blocking p38-α MAPK activity, researchers can explore its role in regulating cytokine production, cell differentiation, and apoptosis. This compound is also utilized in drug discovery efforts to develop potential therapeutic agents targeting p38-α MAPK for treating conditions like rheumatoid arthritis, chronic obstructive pulmonary disease (COPD), and other inflammation-related illnesses. Its application extends to understanding the molecular mechanisms underlying cellular stress responses and identifying novel targets for intervention in pathological processes.