Used as a source of manganese in agricultural applications, particularly in correcting manganese deficiency in soils and crops. It promotes photosynthesis, root growth, and prevents symptoms like interveinal chlorosis, resulting in vibrant green leaves and healthy growth. Commonly applied in liquid fertilizers, micronutrient blends for hydroponics, and foliar sprays, especially for crops like soybeans, wheat, peanuts, citrus, rice, beans, and vegetables.

In animal husbandry, it serves as a nutritional additive in feed, particularly for ruminants, to support growth and milk production.

In industry, manganese sulfate solution acts as an intermediate for producing other manganese compounds, in metal plating processes, in the manufacture of dry cell batteries, and in wastewater treatment to remove sulfur compounds.