Dimethyl 2-ethylidenemalonate is primarily used as a versatile intermediate in organic synthesis. It is commonly employed in the production of fine chemicals, pharmaceuticals, and agrochemicals. Its reactive double bond and ester groups make it a valuable building block for constructing complex molecules through reactions such as Michael additions, cyclizations, and polymerizations. In the pharmaceutical industry, it is utilized to synthesize active pharmaceutical ingredients (APIs) and other bioactive compounds. Additionally, it finds application in the development of polymers and coatings, where its structure contributes to the formation of specialized materials with desired properties. Its role in cross-coupling reactions also makes it useful in advanced material science and catalysis research.