ML351 is primarily used in research settings as a selective inhibitor of the enzyme 15-lipoxygenase-1 (15-LOX-1). This enzyme is involved in the oxidation of polyunsaturated fatty acids and has been linked to inflammatory processes and certain neurodegenerative conditions. By inhibiting 15-LOX-1, ML351 helps scientists study the role of this enzyme in cellular models of oxidative stress and inflammation. It is particularly valuable in neuroscience research, where it has been applied to investigate pathways involved in neuronal cell death. Studies suggest that ML351 may protect neurons from oxidative damage, making it a tool compound for exploring potential therapeutic strategies in diseases like Parkinson’s and other conditions involving lipid peroxidation. Due to its specificity, ML351 is also used to differentiate the effects of 15-LOX-1 from other lipoxygenase isoforms, aiding in the clarification of enzymatic roles in complex biological systems. It is not used clinically and remains restricted to in vitro and preclinical research.