Lipoprotein lipase activators are primarily used to improve lipid metabolism in individuals with hypertriglyceridemia. These compounds enhance the activity of lipoprotein lipase, an enzyme responsible for breaking down triglycerides in the bloodstream. By stimulating this enzyme, they help reduce elevated levels of triglycerides and very-low-density lipoprotein (VLDL), while also increasing high-density lipoprotein (HDL) cholesterol. This action lowers the risk of cardiovascular events such as pancreatitis and atherosclerosis in patients with severe lipid disorders. They are especially beneficial in managing dyslipidemia in patients with metabolic syndrome or type 2 diabetes. Some activators are under investigation for use in genetic lipid disorders where lipoprotein lipase activity is impaired.