Commendamide is primarily studied for its role in modulating the gut microbiota and its potential therapeutic applications in metabolic and inflammatory conditions. It interacts with G protein-coupled receptors (GPCRs) in the gastrointestinal tract, influencing gut barrier function and immune responses. This makes it a promising candidate for managing conditions like inflammatory bowel disease (IBD) and metabolic syndrome. Additionally, commendamide has been explored for its ability to regulate lipid metabolism, which could be beneficial in addressing obesity and related metabolic disorders. Its impact on gut health also suggests potential applications in improving overall digestive wellness and preventing gut-related diseases. Research is ongoing to further understand its mechanisms and therapeutic potential.