PF-8380 is primarily utilized in research settings as a potent and selective inhibitor of autotaxin, an enzyme involved in the production of lysophosphatidic acid (LPA). By inhibiting autotaxin, PF-8380 helps in studying the role of LPA in various physiological and pathological processes, including inflammation, fibrosis, and cancer progression. Its application is significant in preclinical studies aimed at understanding the signaling pathways mediated by LPA and exploring potential therapeutic targets for diseases associated with dysregulated LPA signaling. Additionally, PF-8380 is used in drug discovery efforts to develop novel treatments for conditions such as idiopathic pulmonary fibrosis, rheumatoid arthritis, and certain cancers. Its ability to modulate LPA levels makes it a valuable tool in both basic research and the development of new pharmacological interventions. Research involving PF-8380 remains experimental and requires further studies before potential clinical applications.