Indium(III) trifluoromethanesulfonate is widely used as a Lewis acid catalyst in organic synthesis. It is particularly effective in promoting various reactions, including Friedel-Crafts alkylations and acylations, due to its strong electrophilic nature. The compound is also employed in the synthesis of complex organic molecules, such as natural products and pharmaceuticals, where it facilitates key bond-forming steps. Additionally, it is utilized in the preparation of functionalized polymers and materials, enhancing their properties for specific applications. Its stability and solubility in organic solvents make it a versatile choice for researchers and industrial chemists.