Naloxegol is primarily used in the treatment of opioid-induced constipation (OIC) in adult patients with chronic non-cancer pain. It works by blocking the effects of opioids on the gastrointestinal tract, thereby increasing bowel movements without interfering with the pain relief provided by opioids. This makes it a valuable option for patients who require long-term opioid therapy but struggle with constipation as a side effect. It is typically prescribed when traditional laxatives have not been effective. The medication is taken orally, usually once daily, and should be used under medical supervision to ensure proper dosing and monitoring of potential side effects. Its targeted action helps improve the quality of life for patients managing chronic pain.