ALK2-IN-2 is primarily used in research settings to study and inhibit the activity of the ALK2 kinase enzyme, which plays a significant role in bone morphogenetic protein (BMP) signaling pathways. Its application is crucial in understanding diseases where BMP signaling is dysregulated, such as fibrodysplasia ossificans progressiva (FOP), a rare genetic disorder causing abnormal bone growth. Researchers utilize ALK2-IN-2 to explore potential therapeutic strategies for FOP and other conditions linked to ALK2 overexpression or mutations. Additionally, it aids in studying the broader role of ALK2 in cellular processes, including development, differentiation, and tissue homeostasis. This compound is a valuable tool in drug discovery efforts aimed at developing targeted therapies for ALK2-related disorders.