GSK4028 is primarily utilized in research settings as a potent and selective inhibitor of the protein kinase DYRK1A. Its application is significant in the study of neurodegenerative diseases, particularly Down syndrome and Alzheimer's disease, where DYRK1A dysregulation is implicated. By inhibiting this kinase, researchers can investigate its role in neuronal development and function, potentially leading to the development of therapeutic strategies. Additionally, GSK4028 is used in cellular and molecular biology studies to understand the broader signaling pathways and biological processes influenced by DYRK1A activity. Its specificity makes it a valuable tool for elucidating the mechanisms underlying various pathological conditions and for screening potential drug candidates.