GSK-843 is primarily utilized in research settings as a potent and selective inhibitor of RIP2 kinase. Its application is significant in studying the role of RIP2 kinase in various inflammatory and autoimmune diseases. Researchers employ GSK-843 to investigate the NOD1 and NOD2 signaling pathways, which are crucial in the immune response to bacterial infections. By inhibiting RIP2 kinase, GSK-843 helps in understanding the mechanisms underlying conditions like Crohn's disease, Blau syndrome, and other inflammatory disorders. Additionally, it serves as a valuable tool in preclinical studies to evaluate potential therapeutic strategies targeting RIP2 kinase, aiding in the development of novel treatments for inflammatory diseases.