Skepinone-L is primarily used in biochemical research as a highly selective inhibitor of p38α MAP kinase. This enzyme plays a crucial role in cellular responses to stress and inflammation. By inhibiting p38α, Skepinone-L helps scientists study the signaling pathways involved in inflammatory diseases, cancer, and other conditions where p38α is active. Its specificity makes it a valuable tool for understanding the role of p38α in various biological processes and for developing targeted therapies. Additionally, Skepinone-L is used in preclinical studies to evaluate the potential of p38α inhibition as a treatment strategy for diseases characterized by chronic inflammation or abnormal cell proliferation.