Used in research settings as a selective inhibitor of p38 mitogen-activated protein kinase, TG100-115 helps study inflammatory pathways and cellular responses involved in diseases such as cancer and autoimmune disorders. It is utilized in preclinical experiments to evaluate the role of p38 signaling in tumor progression and immune regulation. Its application supports the development of targeted therapies by providing insights into kinase-dependent mechanisms in cell proliferation and apoptosis.