umbralisib (TGR-1202)
10mM in DMSO
Reagent
Code: #239233
CAS Number
1532533-67-7
blur_circular Chemical Specifications
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Molecular Information
Weight
571.55 g/mol
Formula
C₃₁H₂₄F₃N₅O₃
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Registry Numbers
MDL Number
MFCD28386165
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Storage & Handling
Storage
-20°C
description Product Description
Used in the treatment of certain B-cell malignancies, particularly relapsed or refractory mantle cell lymphoma and chronic lymphocytic leukemia. It functions as a dual inhibitor of PI3K-delta and casein kinase-1-epsilon, helping to block signaling pathways that promote tumor growth and survival. Its selectivity may reduce immune-related toxicities compared to other inhibitors, making it a valuable option in patients who have failed prior therapies. Currently under investigation in clinical trials to expand its use in combination regimens and other hematologic cancers.
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