Torin-1
2mM in DMSO
Reagent
Code: #239225
CAS Number
1222998-36-8
science Other reagents with same CAS 1222998-36-8
blur_circular Chemical Specifications
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Molecular Information
Weight
607.62 g/mol
Formula
C₃₅H₂₈F₃N₅O₂
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Storage & Handling
Storage
-20°C
description Product Description
Torin-1 is a potent and selective inhibitor of mTOR (mechanistic target of rapamycin), a key protein kinase involved in regulating cell growth, proliferation, and survival. It is widely used in research to study the mTOR signaling pathway, particularly the mTOR complex 1 (mTORC1) and mTOR complex 2 (mTORC2). Due to its high specificity and ability to fully inhibit mTOR activity, Torin-1 is employed in cellular and molecular biology experiments to induce autophagy, suppress protein synthesis, and investigate metabolic regulation.
It has also been utilized in cancer research to examine the effects of mTOR inhibition on tumor cell growth and survival, showing potential in sensitizing certain cancer cells to other therapies. Additionally, Torin-1 is used in aging and neurodegenerative disease studies, where modulation of mTOR signaling is linked to lifespan extension and protection against protein aggregation. Its application remains primarily in preclinical research, serving as a tool compound for understanding disease mechanisms and evaluating therapeutic strategies.
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