(S)-N-(3-Chloro-4-fluorophenyl)-6-nitro-7-((tetrahydrofuran-3-yl)oxy)quina zolin-4-amine

99%

Reagent Code: #235158
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CAS Number 314771-88-5

science Other reagents with same CAS 314771-88-5

blur_circular Chemical Specifications

scatter_plot Molecular Information
Weight 404.78 g/mol
Formula C₁₈H₁₄ClFN₄O₄
badge Registry Numbers
EC Number 925-395-5
MDL Number MFCD18642924
thermostat Physical Properties
Boiling Point 585.0±50.0 °C(Predicted)
inventory_2 Storage & Handling
Density 1.534±0.06 g/cm3(Predicted)
Storage  2-8°C

description Product Description

Used as a key intermediate in the synthesis of epidermal growth factor receptor (EGFR) inhibitors, particularly in targeted cancer therapies. It plays a critical role in the development of tyrosine kinase inhibitors (TKIs) that are effective against non-small cell lung cancer (NSCLC) with specific EGFR mutations. Its structural configuration enables selective binding to mutant forms of EGFR, enhancing therapeutic efficacy while minimizing effects on wild-type receptors. This compound is primarily utilized in pharmaceutical research and development for oncology drugs, especially in creating third-generation inhibitors that overcome common resistance mutations like T790M.

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Size Availability Unit Price Quantity
inventory 1g
10-20 days ฿850.00
inventory 5g
10-20 days ฿2,610.00
inventory 25g
10-20 days ฿8,890.00

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(S)-N-(3-Chloro-4-fluorophenyl)-6-nitro-7-((tetrahydrofuran-3-yl)oxy)quina zolin-4-amine
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Used as a key intermediate in the synthesis of epidermal growth factor receptor (EGFR) inhibitors, particularly in targeted cancer therapies. It plays a critical role in the development of tyrosine kinase inhibitors (TKIs) that are effective against non-small cell lung cancer (NSCLC) with specific EGFR mutations. Its structural configuration enables selective binding to mutant forms of EGFR, enhancing therapeutic efficacy while minimizing effects on wild-type receptors. This compound is primarily utilize

Used as a key intermediate in the synthesis of epidermal growth factor receptor (EGFR) inhibitors, particularly in targeted cancer therapies. It plays a critical role in the development of tyrosine kinase inhibitors (TKIs) that are effective against non-small cell lung cancer (NSCLC) with specific EGFR mutations. Its structural configuration enables selective binding to mutant forms of EGFR, enhancing therapeutic efficacy while minimizing effects on wild-type receptors. This compound is primarily utilized in pharmaceutical research and development for oncology drugs, especially in creating third-generation inhibitors that overcome common resistance mutations like T790M.

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