SAR405 is primarily used in biochemical and pharmacological research as a potent and selective inhibitor of PIK3C3/VPS34, an enzyme involved in autophagy regulation. Its main application lies in studying cellular autophagy processes, which play a critical role in cancer, neurodegenerative diseases, and metabolic disorders. By inhibiting VPS34, SAR405 helps researchers dissect the signaling pathways related to vesicle trafficking and autophagosome formation. It is widely used in cell-based assays and preclinical models to evaluate the therapeutic potential of autophagy modulation, particularly in oncology research. Due to its selectivity, SAR405 minimizes off-target effects, making it a valuable tool for probing VPS34-specific functions in complex biological systems.