Used in the treatment of myelofibrosis and polycythemia vera, this compound helps reduce spleen size and alleviate symptoms such as night sweats, weight loss, and bone pain. It is also applied in managing steroid-refractory acute graft-versus-host disease in patients who have not responded to other therapies. Its mechanism involves selective inhibition of JAK1 and JAK2 signaling pathways, which play a key role in inflammation and abnormal blood cell production. Additionally, it has been explored in topical formulations for inflammatory skin conditions, showing efficacy in reducing lesions and itching in conditions like vitiligo and atopic dermatitis.