R788 (Fostamatinib) Disodium
2mM in DMSO
Reagent
Code: #229745
CAS Number
1025687-58-4
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Molecular Information
Weight
624.42 g/mol
Formula
C₂₃H₂₄FN₆O₉P·₂Na
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Registry Numbers
MDL Number
MFCD15146370
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Storage & Handling
Storage
-20°C
description Product Description
Used primarily in the treatment of autoimmune diseases, particularly chronic immune thrombocytopenia (ITP), where it helps increase platelet counts by inhibiting spleen tyrosine kinase (Syk). This action reduces the immune system's destruction of platelets, making it beneficial for patients who have not responded well to other therapies like corticosteroids or splenectomy. Investigated for use in other immune-mediated conditions such as rheumatoid arthritis and autoimmune hemolytic anemia due to its role in modulating immune cell signaling. Also explored in inflammatory diseases because of its impact on Fc receptor-mediated inflammation pathways.
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