Used primarily in the treatment of myelofibrosis and polycythemia vera, it helps reduce spleen size and alleviate symptoms such as night sweats, weight loss, and bone pain. It is also applied in the management of graft-versus-host disease, particularly in patients who have not responded to standard therapies. In dermatology, it is utilized in topical form for the treatment of vitiligo, helping to repigment skin areas affected by the condition. Its mechanism involves inhibiting JAK1 and JAK2 signaling pathways, which play a role in inflammation and abnormal blood cell production.