(1R)-7-Chloro-6-fluoro-1-(2-isopropyl-4-methylpyridin-3-yl)pyrido[2,3-d]pyrimidine-2,4(1H,3H)-dione

98%

Reagent Code: #229522
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CAS Number 2300966-23-6

science Other reagents with same CAS 2300966-23-6

blur_circular Chemical Specifications

scatter_plot Molecular Information
Weight 348.76 g/mol
Formula C₁₆H₁₄ClFN₄O₂
inventory_2 Storage & Handling
Storage 2-8°C

description Product Description

This compound is a potent and selective inhibitor of the delta isoform of phosphoinositide 3-kinase (PI3K), playing a key role in cell signaling pathways related to growth, survival, and immune cell inflammation. It is developed for anticancer therapies and treatment of immune disorders.

In cancer treatment, particularly hematologic malignancies such as leukemia, lymphoma, and myeloma, it inhibits cancer cell proliferation and promotes apoptosis, especially in cells with dysregulated PI3K pathway activity.

Additionally, it shows potential for treating chronic immune-mediated inflammatory conditions, such as rheumatoid arthritis and systemic lupus erythematosus (SLE), by significantly suppressing B lymphocyte and T cell activation.

In vitro and in vivo studies highlight its high specificity and reduced side effects compared to prior PI3K inhibitors, positioning it as a promising lead for new therapeutics in oncology and immunology.

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inventory 1g
10-20 days ฿1,000.00

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(1R)-7-Chloro-6-fluoro-1-(2-isopropyl-4-methylpyridin-3-yl)pyrido[2,3-d]pyrimidine-2,4(1H,3H)-dione
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This compound is a potent and selective inhibitor of the delta isoform of phosphoinositide 3-kinase (PI3K), playing a key role in cell signaling pathways related to growth, survival, and immune cell inflammation. It is developed for anticancer therapies and treatment of immune disorders.

In cancer treatment, particularly hematologic malignancies such as leukemia, lymphoma, and myeloma, it inhibits cancer cell proliferation and promotes apoptosis, especially in cells with dysregulated PI3K pathway a

This compound is a potent and selective inhibitor of the delta isoform of phosphoinositide 3-kinase (PI3K), playing a key role in cell signaling pathways related to growth, survival, and immune cell inflammation. It is developed for anticancer therapies and treatment of immune disorders.

In cancer treatment, particularly hematologic malignancies such as leukemia, lymphoma, and myeloma, it inhibits cancer cell proliferation and promotes apoptosis, especially in cells with dysregulated PI3K pathway activity.

Additionally, it shows potential for treating chronic immune-mediated inflammatory conditions, such as rheumatoid arthritis and systemic lupus erythematosus (SLE), by significantly suppressing B lymphocyte and T cell activation.

In vitro and in vivo studies highlight its high specificity and reduced side effects compared to prior PI3K inhibitors, positioning it as a promising lead for new therapeutics in oncology and immunology.

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