Picropodophyllon
Analytical reference substance, ≥98% (HPLC)
Reagent
Code: #227140
CAS Number
477-48-5
science Other reagents with same CAS 477-48-5
blur_circular Chemical Specifications
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Molecular Information
Weight
412.39 g/mol
Formula
C₂₂H₂₀O₈
thermostat
Physical Properties
Melting Point
153-154 °C
Boiling Point
602.3±55.0 °C at 760 mmHg
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Storage & Handling
Storage
2-8°C
description Product Description
Used in cancer research due to its ability to inhibit the insulin-like growth factor 1 receptor (IGF-1R), which plays a role in tumor cell proliferation and survival. Shows potential as an anti-cancer agent, particularly in studies involving glioblastoma, melanoma, and other solid tumors. Demonstrates cytotoxic effects on cancer cells while sparing normal cells, making it a candidate for targeted therapy development. Also used as a reference compound in biochemical assays studying kinase inhibition and apoptosis induction.
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