PD153035 is a potent and selective inhibitor of the epidermal growth factor receptor (EGFR) tyrosine kinase. It is widely used in research settings to study signal transduction pathways involved in cell proliferation, survival, and differentiation. Due to its ability to block EGFR activation, it serves as a valuable tool in cancer research, particularly in studies focused on tumors driven by EGFR overexpression or mutation, such as non-small cell lung cancer. It is commonly applied in in vitro assays to assess kinase inhibition and to evaluate the downstream effects of EGFR pathway suppression, including reduced phosphorylation of signaling proteins like ERK and AKT. PD153035 also supports investigations into mechanisms of drug resistance in targeted cancer therapies. Its specificity makes it suitable for use in cell-based models where precise modulation of EGFR activity is required.