PD-166866
10mM in DMSO
Reagent
Code: #224196
CAS Number
192705-79-6
blur_circular Chemical Specifications
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Molecular Information
Weight
396.44 g/mol
Formula
C₂₀H₂₄N₆O₃
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Registry Numbers
MDL Number
MFCD12922514
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Storage & Handling
Storage
-20°C
description Product Description
Used primarily in research settings as a potent and selective inhibitor of fibroblast growth factor receptor 1 (FGFR1), this compound plays a key role in studying signaling pathways involved in cell proliferation, differentiation, and survival. It is widely applied in cancer research to investigate the inhibition of FGFR-driven tumor growth, particularly in cancers where FGFR signaling is dysregulated, such as certain types of breast cancer, multiple myeloma, and leukemia. Its ability to cross the blood-brain barrier also makes it valuable in studies targeting central nervous system tumors or neurological disorders involving aberrant FGFR activity. Additionally, it serves as a pharmacological tool to dissect the role of FGFR in developmental biology and tissue repair mechanisms.
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