PF-5274857
10mM in DMSO
Reagent
Code: #224085
CAS Number
1373615-35-0
blur_circular Chemical Specifications
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Molecular Information
Weight
436.96 g/mol
Formula
C₂₀H₂₅ClN₄O₃S
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Registry Numbers
MDL Number
MFCD22420827
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Storage & Handling
Storage
-20°C
description Product Description
Used primarily in research settings as a potent and selective inhibitor of c-Met kinase, an enzyme involved in cell signaling pathways associated with tumor growth and metastasis. It demonstrates strong anti-proliferative effects in cancer cell lines that depend on c-Met signaling, making it a valuable tool compound for studying oncogenic processes and evaluating therapeutic strategies targeting receptor tyrosine kinases. Its high selectivity and blood-brain barrier permeability also support its use in models of central nervous system cancers, aiding in the development of brain-penetrant kinase inhibitors.
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