Used as a potent and selective inhibitor of protein kinase R (PKR) in biochemical and cellular studies, PKR-IN-C16 helps modulate the PKR-mediated signaling pathway, which is involved in inflammation, apoptosis, and antiviral responses. It is commonly applied in research settings to investigate the role of PKR in stress response, neurodegenerative diseases, and viral infection mechanisms. Its cell permeability allows for effective use in cell-based assays to suppress PKR activation and study downstream effects on gene expression and cell survival.