PWT143 (ME-401)
10mM in DMSO
Reagent
Code: #224080
CAS Number
1595129-71-7
science Other reagents with same CAS 1595129-71-7
blur_circular Chemical Specifications
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Molecular Information
Weight
678.81 g/mol
Formula
C₃₈H₅₀N₂O₉
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Storage & Handling
Storage
-20°C
description Product Description
Used in clinical research for the treatment of various B-cell malignancies, including relapsed or refractory non-Hodgkin lymphoma and chronic lymphocytic leukemia. It functions as a selective inhibitor of phosphoinositide 3-kinase delta (PI3Kδ), a key signaling molecule involved in B-cell proliferation, survival, and migration. By targeting this pathway, it helps suppress abnormal B-cell growth and promotes apoptosis in malignant cells. Currently under investigation in phase 1 and 2 trials to evaluate safety, efficacy, and optimal dosing in hematologic cancers.
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