N-(4-((6-Methoxy-7-(3-Morpholinopropoxy)quinazolin-4-yl)aMino)phenyl)benzaMide
10mM in DMSO
Reagent
Code: #216345
CAS Number
331771-20-1
blur_circular Chemical Specifications
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Molecular Information
Weight
513.6 g/mol
Formula
C₂₉H₃₁N₅O₄
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Registry Numbers
MDL Number
MFCD08703125
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Physical Properties
Melting Point
117-120 °C
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Storage & Handling
Storage
-20°C
description Product Description
Used as a potent inhibitor in targeted cancer therapies, particularly in the treatment of certain tyrosine kinase-driven tumors. It interferes with signaling pathways involved in cell proliferation and survival, especially those associated with epidermal growth factor receptor (EGFR) and related kinases. Its structure allows selective binding to mutant forms of these receptors, making it effective in cancers like non-small cell lung carcinoma. The compound is studied for its ability to overcome resistance seen with earlier generation inhibitors, providing a therapeutic option in resistant or relapsed cases. It is also explored in combination therapies to enhance antitumor efficacy and improve patient outcomes.
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