Methyl (4,6-diaMino-2-(1-(2-fluorobenzyl)-1H-pyrazolo[3,4-b]pyridin-3-yl)pyriMidin-5-yl)(Methyl)carbaMate
10mM in DMSO
Reagent
Code: #204463
CAS Number
625115-55-1
blur_circular Chemical Specifications
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Molecular Information
Weight
422.4 g/mol
Formula
C₂₀H₁₉FN₈O₂
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Storage & Handling
Storage
-20°C
description Product Description
Used in pharmaceutical research as a potent inhibitor of cyclin-dependent kinases (CDKs), particularly CDK9, which plays a key role in transcription regulation. This compound shows promise in oncology for disrupting cancer cell proliferation and inducing apoptosis, especially in hematological malignancies. It is studied for its ability to suppress short-lived oncoproteins by blocking RNA polymerase II phosphorylation. Its selectivity and potency make it a candidate for targeted cancer therapy development. Also used as a biochemical tool to study CDK-mediated signaling pathways in cellular models.
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