Used to treat cancers with specific NTRK gene fusions, particularly in patients with solid tumors that have spread or cannot be removed by surgery. Effective in both adult and pediatric populations across various tumor types, including salivary gland, thyroid, lung, and soft tissue sarcomas. Shows high response rates and durable responses, even in advanced stages. Preferred when tumors test positive for NTRK fusion without other effective treatment options. Can cross the blood-brain barrier, making it useful for central nervous system involvement. Administered orally, allowing for convenient outpatient treatment.