Used to treat cancers with specific genetic alterations involving NTRK gene fusions. Effective in tumors regardless of location in the body or patient age. Commonly used in pediatric and adult patients with solid tumors that have progressed after prior treatments or when surgery is not an option. Shows high response rates and durable responses in cancers such as sarcomas, thyroid cancer, and certain brain tumors. Particularly valuable in cases where the tumor has spread or is hard to remove surgically. Works by inhibiting abnormal TRK proteins that drive cancer growth.