LJH685 is primarily used in research settings as a selective inhibitor of the MNK1/2 (MAP kinase-interacting kinases) pathway. It is valued for its ability to modulate eIF4E phosphorylation, a key step in the regulation of mRNA translation, which plays a role in oncogenesis and tumor progression. Due to this mechanism, LJH685 is investigated for its potential in cancer therapy, particularly in hematological malignancies and solid tumors where dysregulated protein synthesis contributes to disease progression. It is also employed as a tool compound in biochemical assays to study signaling pathways linked to inflammation, cell proliferation, and survival. Its high selectivity and cellular permeability make it suitable for in vitro and in vivo pharmacological studies aimed at validating MNK as a therapeutic target.