Used as a potent and selective inhibitor of c-Jun N-terminal kinase (JNK) in research settings, particularly in studies related to cellular stress, inflammation, and apoptosis. It is valued for its ability to cross the blood-brain barrier, making it useful in neuroscience research, especially in models of neurodegenerative diseases. Also employed in cancer research to investigate JNK signaling pathways involved in tumor progression and cell survival. Its high selectivity allows for targeted modulation of JNK activity with minimal off-target effects, supporting its use in mechanistic studies and potential therapeutic development.