9-(1-hydroxyethyl)-7-methyl-2-morpholino-4H-pyrido[1,2-a]pyrimidin-4-one

98%

Reagent Code: #197557
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CAS Number 1173900-35-0

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Weight 289.33 g/mol
Formula C₁₅H₁₉N₃O₃
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MDL Number MFCD18206951
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Used primarily in research settings as a potent and selective inhibitor of cyclin-dependent kinases (CDKs), particularly CDK9. This compound plays a key role in studies related to transcription regulation, especially in cancer cell proliferation. By inhibiting CDK9, it disrupts the phosphorylation of RNA polymerase II, leading to reduced expression of short-lived oncoproteins such as Mcl-1, which are critical for tumor cell survival. As a result, it is widely used in oncology research to induce apoptosis in cancer cells, particularly in hematological malignancies like leukemia and lymphoma. Its morpholino and hydroxyethyl functional groups enhance solubility and target binding, making it a valuable tool compound in kinase inhibitor development and mechanistic studies of transcriptional control.

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Size Availability Unit Price Quantity
inventory 100mg
10-20 days ฿25,740.00

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