Used in research as a potent and selective inhibitor of apoptosis signal-regulating kinase 1 (ASK1), this compound is valuable in studying cellular stress pathways linked to inflammation, neurodegenerative diseases, and ischemic injury. It helps modulate signaling cascades involved in cell death and survival, making it a tool compound in developing therapies for conditions such as Parkinson’s disease, liver fibrosis, and myocardial infarction. Its structure supports blood-brain barrier penetration, enhancing its utility in neurological research. Commonly employed in in vitro and in vivo models to probe kinase-dependent mechanisms and validate ASK1 as a therapeutic target.