4-Fluoro-1H-indazole-6-carbonitrile

≥98%

Reagent Code: #192710
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CAS Number 1082041-49-3

science Other reagents with same CAS 1082041-49-3

blur_circular Chemical Specifications

scatter_plot Molecular Information
Weight 161.14 g/mol
Formula C₈H₄FN₃
badge Registry Numbers
MDL Number MFCD11007865
thermostat Physical Properties
Boiling Point 364.2±22.0 °C(Predicted)
inventory_2 Storage & Handling
Density 1.44±0.1 g/cm3(Predicted)
Storage 2-8°C, sealed, dry

description Product Description

Used as a key intermediate in the synthesis of pharmaceutical compounds, particularly in the development of kinase inhibitors for cancer treatment. It serves as a building block in medicinal chemistry due to the presence of both the nitrile and indazole functionalities, which are known to enhance binding affinity to biological targets. Commonly employed in the preparation of potent and selective inhibitors targeting enzymes such as PDE10A and FLT3, which are implicated in neurological disorders and leukemia. Its fluorinated structure improves metabolic stability and membrane permeability, making it valuable in optimizing drug candidates for in vivo efficacy. Also utilized in agrochemical research for designing bioactive molecules with enhanced activity and selectivity.

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Size Availability Unit Price Quantity
inventory 250mg
10-20 days ฿27,990.00
inventory 1g
10-20 days ฿34,990.00

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4-Fluoro-1H-indazole-6-carbonitrile
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Used as a key intermediate in the synthesis of pharmaceutical compounds, particularly in the development of kinase inhibitors for cancer treatment. It serves as a building block in medicinal chemistry due to the presence of both the nitrile and indazole functionalities, which are known to enhance binding affinity to biological targets. Commonly employed in the preparation of potent and selective inhibitors targeting enzymes such as PDE10A and FLT3, which are implicated in neurological disorders and leukemia. Its fluorinated structure improves metabolic stability and membrane permeability, making it valuable in optimizing drug candidates for in vivo efficacy. Also utilized in agrochemical research for designing bioactive molecules with enhanced activity and selectivity.
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