4-Fluoro-1H-indazole-6-carbonitrile
≥98%
Reagent
Code: #192710
CAS Number
1082041-49-3
science Other reagents with same CAS 1082041-49-3
blur_circular Chemical Specifications
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Molecular Information
Weight
161.14 g/mol
Formula
C₈H₄FN₃
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Registry Numbers
MDL Number
MFCD11007865
thermostat
Physical Properties
Boiling Point
364.2±22.0 °C(Predicted)
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Storage & Handling
Density
1.44±0.1 g/cm3(Predicted)
Storage
2-8°C, sealed, dry
description Product Description
Used as a key intermediate in the synthesis of pharmaceutical compounds, particularly in the development of kinase inhibitors for cancer treatment. It serves as a building block in medicinal chemistry due to the presence of both the nitrile and indazole functionalities, which are known to enhance binding affinity to biological targets. Commonly employed in the preparation of potent and selective inhibitors targeting enzymes such as PDE10A and FLT3, which are implicated in neurological disorders and leukemia. Its fluorinated structure improves metabolic stability and membrane permeability, making it valuable in optimizing drug candidates for in vivo efficacy. Also utilized in agrochemical research for designing bioactive molecules with enhanced activity and selectivity.
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