Used in research for its potent and selective inhibition of glycogen synthase kinase-3 (GSK-3), particularly the GSK-3β isoform. It is employed in studies related to neurodegenerative diseases, such as Alzheimer's, where GSK-3 overactivity is linked to tau protein hyperphosphorylation. Also utilized in cancer research due to GSK-3's role in cell proliferation and survival pathways. Shows utility in stem cell research by modulating Wnt signaling, aiding in the maintenance of pluripotency. Its high selectivity makes it a valuable tool for probing GSK-3-dependent biological processes without significant off-target effects.