GNE0877 is primarily used in scientific research as a potent and selective inhibitor of TANK-binding kinase 1 (TBK1). It is employed to study signaling pathways involved in inflammation, immune response, and cancer progression. Due to its ability to modulate TBK1 activity, it has become a valuable tool in investigating oncogenic signaling, particularly in cancers driven by mutations in KRAS or other pathways where TBK1 plays a supportive role. Researchers also use GNE0877 to explore the role of TBK1 in autophagy and cellular survival mechanisms. Its application remains confined to preclinical studies, aiding in target validation and the development of potential therapeutic strategies.