GNE-7915 is a potent and selective inhibitor of the Tropomyosin receptor kinase (TRK) family, particularly TRKA. It has been primarily used in research settings to study oncogenic signaling pathways driven by TRK fusion proteins, which are implicated in certain cancers. By inhibiting TRK kinase activity, GNE-7915 helps suppress tumor cell proliferation and survival in preclinical models. It serves as a valuable tool compound for validating TRK as a therapeutic target and for understanding resistance mechanisms to TRK inhibitors. Its application is mainly confined to in vitro and in vivo research, aiding the development of targeted cancer therapies.