Used primarily in research settings as a selective inhibitor of receptor-interacting protein kinase 3 (RIPK3), GSK-872 hydrochloride is instrumental in studying necroptosis, a form of regulated cell death. It helps elucidate signaling pathways involved in inflammatory diseases, neurodegeneration, and ischemia-reperfusion injury. By blocking RIPK3 activity, it allows scientists to dissect the role of necroptosis in disease models and evaluate potential therapeutic strategies targeting cell death mechanisms. Its application is largely confined to preclinical research and is not used clinically.