(E)-3-(3-(3,5-Bis(Trifluoromethyl)Phenyl)-1H-1,2,4-Triazol-1-Yl)-2-Bromoacrylamide
98%
Reagent
Code: #185677
CAS Number
1642300-95-5
blur_circular Chemical Specifications
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Molecular Information
Weight
429.12 g/mol
Formula
C₁₃H₇BrF₆N₄O
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Storage & Handling
Storage
Room temperature
description Product Description
Used as a potent inhibitor in biochemical research, particularly targeting specific enzymes involved in cellular signaling pathways. It is commonly applied in studies related to protein degradation, including proteolysis-targeting chimeras (PROTACs) and kinase inhibition. Its electrophilic acrylamide group enables covalent binding to cysteine residues in target proteins, enhancing selectivity and prolonging inhibitory effects. Due to its bromine and trifluoromethyl groups, it exhibits high lipophilicity and membrane permeability, making it suitable for cell-based assays. Frequently employed in cancer research for modulating oncogenic proteins and evaluating therapeutic targets.
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