Entospletinib

10mM in DMSO

Reagent Code: #181500
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CAS Number 1229208-44-9

blur_circular Chemical Specifications

scatter_plot Molecular Information
Weight 411.46 g/mol
Formula C₂₃H₂₁N₇O
badge Registry Numbers
MDL Number MFCD28099806
inventory_2 Storage & Handling
Storage -20°C

description Product Description

Used primarily in the treatment of hematologic malignancies, particularly acute myeloid leukemia (AML). It functions as a selective inhibitor of spleen tyrosine kinase (Syk), which plays a key role in signaling pathways involved in immune cell activation and survival of malignant B-cells. By blocking Syk, it helps suppress the proliferation and survival of cancer cells. It has been investigated in clinical trials both as a monotherapy and in combination with other agents such as chemotherapy or targeted therapies. Its selectivity may offer a favorable safety profile compared to broader kinase inhibitors, making it a candidate for patients who are not responsive to standard treatments. Research also explores its potential in other B-cell-related malignancies and inflammatory conditions where Syk signaling is dysregulated.

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Size Availability Unit Price Quantity
inventory 1ml
10-20 days ฿7,250.00

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