Entospletinib
10mM in DMSO
Reagent
Code: #181500
CAS Number
1229208-44-9
blur_circular Chemical Specifications
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Molecular Information
Weight
411.46 g/mol
Formula
C₂₃H₂₁N₇O
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Registry Numbers
MDL Number
MFCD28099806
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Storage & Handling
Storage
-20°C
description Product Description
Used primarily in the treatment of hematologic malignancies, particularly acute myeloid leukemia (AML). It functions as a selective inhibitor of spleen tyrosine kinase (Syk), which plays a key role in signaling pathways involved in immune cell activation and survival of malignant B-cells. By blocking Syk, it helps suppress the proliferation and survival of cancer cells. It has been investigated in clinical trials both as a monotherapy and in combination with other agents such as chemotherapy or targeted therapies. Its selectivity may offer a favorable safety profile compared to broader kinase inhibitors, making it a candidate for patients who are not responsive to standard treatments. Research also explores its potential in other B-cell-related malignancies and inflammatory conditions where Syk signaling is dysregulated.
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