4-[[4-[[4-[(E)-2-cyanoethenyl]-2, 6-dimethyl-phenyl]amino]pyrimidin-2-yl]amino]benzonitrile
10mM in DMSO
Reagent
Code: #181306
CAS Number
500287-72-9
blur_circular Chemical Specifications
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Molecular Information
Weight
366.42 g/mol
Formula
C₂₂H₁₈N₆
thermostat
Physical Properties
Melting Point
245 °C
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Storage & Handling
Storage
-20°C
description Product Description
Used as a key intermediate in the synthesis of tyrosine kinase inhibitors, particularly in targeted cancer therapies. It plays a role in the development of pharmaceuticals that inhibit abnormal protein signaling in tumor cells, especially in treatments for chronic myeloid leukemia (CML) and non-small cell lung cancer (NSCLC). Its structure enables strong binding to specific kinase domains, enhancing the selectivity and efficacy of the drug while minimizing off-target effects. Also investigated for use in next-generation anticancer agents due to its stability and ability to cross cell membranes effectively.
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