Dovitinib (TKI-258, CHIR-258)
10mM in DMSO
Reagent
Code: #168924
CAS Number
405169-16-6
blur_circular Chemical Specifications
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Molecular Information
Weight
392.43 g/mol
Formula
C₂₁H₂₁FN₆O
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Registry Numbers
MDL Number
MFCD10565680
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Storage & Handling
Storage
-20°C
description Product Description
Dovitinib is primarily used in cancer research and development of targeted therapies. It functions as a multi-kinase inhibitor, showing activity against a range of receptor tyrosine kinases involved in tumor growth and angiogenesis, including FGFR, VEGFR, PDGFR, and FLT3. Due to its broad inhibitory profile, it has been investigated in clinical trials for various cancers such as renal cell carcinoma, breast cancer, and leukemia. Its ability to block signaling pathways that promote tumor progression makes it a valuable tool in studying resistance mechanisms and combination therapies in oncology. Dovitinib is also used in preclinical studies to understand kinase-driven tumorigenesis and to evaluate potential biomarkers for treatment response.
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