CO-1686 (AVL-301)
10mM in DMSO
Reagent
Code: #157801
CAS Number
1374640-70-6
science Other reagents with same CAS 1374640-70-6
blur_circular Chemical Specifications
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Molecular Information
Weight
555.55 g/mol
Formula
C₂₇H₂₈F₃N₇O₃
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Storage & Handling
Storage
-20°C
description Product Description
Used in targeted cancer therapy, particularly for non-small cell lung cancer with specific EGFR mutations. It selectively inhibits mutant forms of EGFR, including the T790M resistance mutation, while sparing wild-type EGFR, reducing side effects. This makes it effective in patients who have developed resistance to first-generation EGFR inhibitors. Its design allows for sustained target inhibition and improved therapeutic outcomes in refractory cases.
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